Is fluorescein dye toxic?

[1,2,3] Fluorescein toxicity may present as headache, paresthesias, seizures and vomiting. [1,4,5] Severe complications such as epileptic crisis, grand mal epilepsy, opisthotonous and peripheral nerve palsy are always secondary to use of higher concentrations.

Is fluorescein hazardous?

Eye: May cause mild eye irritation. Skin: May cause mild skin irritation. Ingestion: Ingestion of large amounts may cause gastrointestinal irritation. Inhalation: Inhalation of dust may cause respiratory tract irritation.

Is fluorescein sodium toxic?

Safety. Oral and intravenous use of fluorescein can cause adverse reactions, including nausea, vomiting, hives, acute hypotension, anaphylaxis and related anaphylactoid reaction, causing cardiac arrest and sudden death due to anaphylactic shock.

What is fluorescein dye made of?

Fluorescein is an organic compound that has wide use as a synthetic coloring agent. It is prepared by heating phthalic anhydride and resorcinol over a zinc catalyst, and it crystallizes as a deep red powder.

Which is the most common side effect complication of fluorescein dye?

The most common reaction is temporary yellowish discoloration of the skin and urine. Urine may attain a bright yellow color. Discoloration of the skin usually fades in 6 to 12 hours and usually fades in urine in 24 to 36 hours.

How long does fluorescein stay in your system?

Your skin may have a yellowish discoloration for about 6 to 12 hours after your test. Your urine may appear bright yellow for up to 36 hours after your test.

Is fluorescein dye harmful to kidneys?

FA showed a significant increase in early sensitive acute kidney injury biomarkers (as serum cystatin C and uNGAL) in substantial number of patients, suggesting but still not proving, a potential harmful effect of FA on kidney functions.

Is fluorescein toxic to humans?

[1,2,3] Fluorescein toxicity may present as headache, paresthesias, seizures and vomiting. [1,4,5] Severe complications such as epileptic crisis, grand mal epilepsy, opisthotonous and peripheral nerve palsy are always secondary to use of higher concentrations.

Does fluorescein dye affect kidneys?

Fluorescent angiography (FAG) with fluorescein sodium dye is generally considered to be safe for patients with kidney diseases.

What are the side effects of fluorescein?

Side Effects

• Bluish color.
• cold, clammy skin.
• difficulty breathing.
• difficulty swallowing.
• fast heartbeat.
• hives, itching, or skin rash.
• lightheadedness.
• noisy breathing.

How long does it take for fluorescein to wear off?

Fluorescein has no known significant drug interactions. Under ophthalmic examination, contact lens removal is necessary with the use of fluorescein to avoid unnecessary staining. [2] Fluorescein completely clears through urine excretion 2 to 3 days after injection.